A series of (benzamidostyryl)benzimidazole derivatives were synthesized by hydrolyzing 2-phenyl-4-(substituted)benzylidene-5-oxazolones, the azlactone precursors in an acidic medium and treating the product with substituted o-phenylenediamine (OPDA) in situ. The structures of the synthesized compounds were confirmed by spectral and elemental analyses. All synthesized compounds were screened for...

AIMS To investigate the appropriateness of the extended Lambert-Pearson model (ELPM) to model the effect of pH (as hydrogen and hydroxyl ions) over the whole biokinetic pH range in comparison with other available models. METHODS AND RESULTS Data for the effect of pH on microbial growth were obtained from the literature or in-house. Data were examined using several models for pH. Models were c...

For decades, fungi have been the main source for the discovery of novel antimicrobial drugs. Recent sequencing efforts revealed a still high number of so far unknown "cryptic" secondary metabolites. The production of these metabolites is presumably epigenetically silenced under standard laboratory conditions. In this study, we investigated the effect of six small mass chemicals, of which some a...

Total polyphenols content and a partial phenolics composition from pulp and peel of organically and conventionally produced Malus domestica, Annurca were investigated. Furthermore, the antimicrobial effect of these compounds against useful and pathogen microorganism was examined. Finally, their mutagenic activities were evaluated. Organically grown apples showed a greater content of polyphenols...

introduction: denture stomatitis is a common complication in patients wearing dentures and preventing the proliferation of related microorganisms and their induced infections is noteworthy. the aim of the present study was to assess the antimicrobial effect of acrylic resins containing various concentrations of silver nanoparticles, on candida albicans and streptococcus mutans. materials and me...

objective: microorganisms are responsible for many problems in industry and medicine because of biofilm formation. therefore, this study was aimed to examine the effect of thymus vulgaris (t. vulgaris) extracts on the planktonic form and biofilm structures of six pathogenic bacteria. materials and methods: antimicrobial activities of the plant extracts against the planktonic form of the bacteri...

background: applications of natural ingredients not only increase the shelf life of food but also omit the problems of synthetic preservatives compounds. objective: cinnamon verum essential oil (cveo 0.05, 0.1, 0.15%) and echinacea purpurea extract (epe 0.25, 0.5, 0.75%) were added to kolompe (a traditional cookie in kerman-iran) and their antioxidant and antimicrobial effects were compared wit...

Freeze-dried juice obtained from Aloe vera and heated for 15 minutes at 80 degrees inhibited several test microorganisms. Species of Aloe have had a long history as drug plants. This was pointed out by Morton (1) in a recent comprehensive review of Aloe from the standpoint of folk use and commercial exploitation. Fly and Kiem (2) recently carried out an investigation to ascertain whether Aloe v...

Although many parameters have been described to quantitate the killing and regrowth of bacteria, substantial shortcomings are inherent in most of them, such as low sensitivity to pharmacokinetic determinants of the antimicrobial effect, an inability to predict a total effect, insufficient robustness, and uncertain interrelations between the parameters that prevent an ultimate determination of t...

Defensins are antimicrobial peptides important to innate host defense. In addition to their direct antimicrobial effect, defensins modulate immune responses. Increasing evidence indicates that defensins exhibit complex functions by positively or negatively modulating infections of both enveloped and non-enveloped viruses. The effects of defensins on viral infections appear to be specific to the...